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Additionally, the Spearman's rank correlation coefficients for the distribution of the candidate surrogates and 5-year OS at the individual level were calculated to assess the strength of the associations, using a bivariate survival model [ 17]; ρ reflects the amount of variation explained by the surrogate.
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We analysed the data at the patient level using a bivariate random effects regression model [ 15].
The differences in sensitivities and specificities were tested using a bivariate random effect model.
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