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An adjustment using a binomial probability distribution could be used to account for possible errors.
We test whether the observed number O is greater than the expected number E at a statistical level α′ using a binomial probability test.
An approximate confidence interval for sequence saturation is derived using a binomial probability model and is given by μ ± 2 μ 1 − μ n, where μ is a given standard methylation ratio, and n is the number of sequenced reads covering the region of interest.
The members of each pair of reads were slid along each other, and, for each overlap of length n, we calculated the probability of getting the observed number of matches k by chance using a binomial probability given by (1) P (k | n ) = n k 1 4 k 3 4 n − k assuming any of the four nucleotides is equally likely to be at any position.
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Given the paucity of data, we chose in practice to assume independence and use a binomial probability to attribute cases to human transmission vs. infection from the reservoir.
To test whether the sex ratios among the Norwegian-Indian births were significantly different from the average sex ratio of all Norwegian births we used a binomial probability model analysing each period and each birth order separately.
Using a binomial-probability test, we identified nine patterns of responses (see Appendix C on how they were obtained).
The dose inheritance is modeled using a binomial partitioning probability to decide which daughter inherits each vesicle.
Mosquito survival is determined once per feeding cycle using a binomial distribution with probability S. Infection of a susceptible mosquito during feeding is dependent on at least one male and one female gametocyte being ingested in the bloodmeal.
Then, n1, n2 and n12 responses out of N attempts were generated using a binomial model with probability of success p1, p2 and p12, respectively.
We then use a phasing algorithm to examine each pair of adjacent polymorphic sites and, using a binomial distribution, calculate the probability that the phase orientation for a specific HLA allele pair is consistent with the sequence data at those sites.
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