Marker accuracy was analyzed using linear mixed effects models as implemented in the lmer-function of the lme4 package (Bates, Maechler, Bolker, & Walker, 2015) for R (R Development Core Team, 2012), using a binomial link function and the Bobyqa optimizer.
Using a binomial fitted function, the children's estimated myopic shift would be 1.94 D at the age of 18 years.
The model was then translated from NONMEM to the Berkeley Madonna software to enable, using a binomial (event) function, the simulation, accumulation, and plotting of inflammatory flares.
The two-part model first describes the probability of a zero or boundary value (π Aij,) for the ith subject at the jth time point using a binomial logistic function: where PRB describes the probability that the PD observation is zero in the absence of measurable drug levels, and Slope is the estimated effect of active drug concentration (Cp).
These models used presence/absence of totara as the dependent variable, and were fitted using a binomial distribution and logit link function that included an exponential spatial covariance error structure.
We parameterized the model using a binomial response distribution, logit inverse link function, and constant subject-specific random effect (detailed information on the model, estimation procedure, and code are available upon request).
Models 2 and 4 were fitted using a binomial error structure and logit link function.
We modelled the binary response variable infection status using a binomial distribution with a logit link function.
Association of characteristics of schools (number of pupils, proportion of pupils eligible for free school meals, geographic area, involvement in substudy) and delivery of the education program were examined with generalised linear regression models using a binomial distribution and a log link function.
Separately for each definition, the proportion of women in each group meeting the criteria will be estimated, and the risk of the outcome in the intervention group relative to the control group will be calculated (i.e., risk ratio) using a binomial regression model with log link function.
