Interference with these ectonucleotidases by use of small molecule inhibitors or inhibitory antibodies appears to be an effective strategy to enhance anti-tumour immunity and suppress neoangiogenesis.
The use of small molecule inhibitors demonstrated that the activation of the p38, but not ERK, pathway was linked to elevated MMP-2, -9, and -14 expression levels in mesangial cells from integrin α1-null mice.
However, inhibition of only the caveolar pathway whether through the use of small molecule drugs or RNA interference reduces gene delivery efficiency, suggesting that successful polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.
Several approaches, including the use of small molecule acceptors, novel polymer structures, and tandem cell structures, have been adopted to prepare polymer solar cells displaying high power conversion efficiencies (PCEs).
To test this possibility we made use of small molecule HDAC inhibitors (HDACi).
We investigated the potential involvement of these and other proteolytic pathways in SMP30 processing by making use of small molecule inhibitors of proteolysis.
These findings suggest that the use of small molecule p75NTR ligands may be a therapeutically feasible approach to AD capable of simultaneously targeting multiple underlying pathogenic mechanisms.
As an alternative to substrate-based reporters, we have recently described the use of small molecule activity based probes that carry a fluorescent reporter [3], [4].
Of potential therapeutic importance, we have demonstrated that cancer cells with aberrant β-catenin activity exhibit greatly increased sensitivity to CK1ε inhibition, mediated either by RNAi or by use of small molecule inhibitors of CK1ε (Figs. 2, 3).
Through the use of small molecule inhibitors, TGF-β signalling was shown to play a vital role in the regulation of E-cadherin and F-actin co-localisation and epithelial paracellular permeability.
The lasI/lasR quorum sensing system responsible for the production of 3O-C12 has has previously been identified as a potential therapeutic target in CF. Antagonizing bacterial production of 3O-C12, either by immunization [38] or through the use of small molecule inhibitors of lasR [49], [50], results in decreased mortality in animal models of P. aeruginosa lung infection.
