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Aiming to enhance its ability to escape from premature convergence, particle uses Metropolis acceptance criterion to decide whether to accept newly produced solutions.
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Markov Chain Monte Carlo (MCMC) method using Metropolis Hastings algorithm is used to obtain the posterior distribution of parameters.
This process will be repeated until a new position is accepted using metropolis acceptance rule, or the termination criterion is reached.
From all these figures, it can be observed that using metropolis mechanism can significantly enhance the performance of the original MFO.
Fortunately, the probability ratio between any two subgraphs is easy to compute; thus, we can use Metropolis algorithm to sample distribution (mathcal {G}^{prime }) in a Markov chain Monte Carlo.
We use Metropolis–Hastings MCMC to estimate the parameters (conditions given in the Supplementary Data).
The used Metropolis procedure did not approach the recommended thousand moves per a degree of freedom.
The remaining parameters were simulated using Metropolis algorithm with a normal proposal distribution.
After the induction of the reprogramming factors, using Metropolis algorithm, Si or Gi is adjusted according to transition probability.
In the case of RNA kinetics, computations of MFPT to reach the minimum free-energy structure take inordinate amounts of time, when using Metropolis–Hastings Monte Carlo methods, which are time-driven simulations.
Finally, we generated time-course gene expression log2-fold-changes that reflect temporal transitions of the synthetic TDN model using Metropolis–Hastings algorithm (Hastings, 1970; Supplementary Figs S3D and S4C).
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