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Drug companies are the most enthusiastic users of toxicogenomics.
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However, the development of flexible and comprehensible data exchange platforms that meet the needs of multiple user groups is essential for routine exchange of toxicogenomics data.
These user stories may guide the prioritization of steps to be taken for enhancing integration of toxicogenomics databases.
For the integration of toxicogenomics information, the Comparative Toxicogenomics Database (CTD) was constructed by curating chemical gene/protein interactions from more than 100,000 selected articles for a decade [1, 2].
The current issues limiting the application of toxicogenomics to define mode or mechanism of action in risk assessment are discussed together with interrelated research needs.
Rapid advancements have been made, but considerable challenges need to be met before the full potential of toxicogenomics can be realised for studies in fish.
Also, the emerging field of toxicogenomics and other high-throughput technologies such as proteomics are now being used widely in nanotoxicity studies, ultimately leading to new biomarker discovery.
The methods of toxicogenomics might be classified into omics study (e.g., genomics, proteomics, and metabolomics) and population study focusing on risk assessment and gene environment interaction.
The application of toxicogenomics as a predictive tool for chemical risk assessment has been under evaluation by the toxicology community for more than a decade.
No respondents felt that these promises of toxicogenomics were near.
John Balbus deals with technical and sociopolitical challenges to the implementation of toxicogenomics, identifying how toxicogenomics may be used to address the limitations of conventional toxicological testing.
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