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The careful selection and reporting of baseline characteristics can facilitate the translation of research results into patient care, and this increases the usefulness of trial results.
Other studies have sought to assess the usefulness of trial specific tailored information while others have focused on reducing the reading levels of informed consent documents.
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70 Explanation The usefulness of the trial report is critically dependent on how applicable the trial and its results are and how feasible the intervention would be.
Recent papers discussed include two large, multicentre, high-positive end-expiratory pressure trials in acute lung injury and reflects upon the usefulness of such trial designs.
Lack of standardization of outcome measures limits the usefulness of clinical trial evidence to inform health care decisions.
5 The usefulness of a trial report also depends on the clarity with which it details the relevance of its interventions, participants, outcomes, and design to the clinical, health service, or policy question it examines.
The usefulness of clinical trials and systematic reviews is compromised when they report different outcomes.
The low prevalence of specific combinations, the high prevalence of psychiatric and social problems and the general complexity of multimorbidity will hamper the usefulness of randomized trials or guidelines at practice level.
Of several factors that need to be taken into account in order to maximize the usefulness of any clinical trial on the value of genotype-guided dosing, the main one is the precise questions to be asked.
Recently, it was pointed out that the enrollment of patients with less severe disease, who are less likely to benefit from a drug or treatment, may reduce the usefulness of randomized controlled trial findings for clinical and policy applications [ 25].
There is published work on the various ways that qualitative methods are being used in RCTs (e.g. [ 12, 13] but little on how they can optimally enhance the usefulness and policy relevance of trial findings.
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