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Regarding ratio of %FEV1 to %FVC, we chose 1.2 which was most useful threshold for predictor of mortality using ROC analysis (ROC: 0.7671).
Other authors have tried to define a useful threshold based on distribution characteristics, for example by using the mean plus one s.d. in the general population (Holzner et al, 2003).
The value of DP 300 could therefore serve as a useful threshold value of DP for the estimation of risk of accumulation of missing pieces and reaching the end of fitness for reading/handling, which is in agreement with the literature discussed in the introduction.
ROC analysis showed that the useful threshold was 1050 (ROC =0.7720).
Indeed, the fairly large inter-patient variability observed in absolute variations of Doppler parameters induced by the SBT precluded the determination of a clinically useful threshold value.
When 'abnormal wear' was defined as that ≥ 3 mm per year, clinically the most useful threshold level appeared to be a blood Co concentration of 5.04 µg/l.
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The results of this study provide potentially useful thresholds of improvement in PROs that go beyond the threshold of minimal importance established for these tools.
However, additional validation is warranted to determine whether clinically useful thresholds can be defined and to better characterize their role in conjunction with other biomarkers during monitoring patients in AS.
Additional validation is warranted to determine whether clinically useful thresholds can be defined and to better characterize the role of %[−2]proPSA and PHI in conjunction with other markers in monitoring patients enrolled in AS in the future.
99 Moreover, all of the sexual dysfunctions outlined in the DSM-5 require a minimum duration of approximately 6 months, and more precise severity criteria must be met in order to provide useful thresholds for making a diagnosis and for distinguishing transient sexual difficulties from more persistent sexual dysfunction.
The 90th and 95th percentiles are the most useful thresholds for elevated BP in any given child.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com