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Distinguishing exposures of limited duration or periods of specific relevance (e.g., in utero) from chronic exposures may lend useful specificity for addressing some research questions.
As a declared drug target for diabetes since 1998, this shows useful specificity as a document keyword search.
We demonstrated that compound 4, formulated either as a Triton X-100 emulsion or incorporated in synthetic HDL particles can serve as a substrate for plasma EL with useful specificity.
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Further research, for example, whether different levels of sensitivity of arrays could produce a useful level of specificity, or the usefulness of other thyroid-specific gene transcripts, such as TPO-mRNA, should however be performed; further thought should also be given to the use of complete gene profiles of the tumour in the follow-up of differentiated thyroid carcinoma.
However, the Gdf5 promoter can be very useful when chondrocyte specificity is not required but joint specificity is.
Although useful, power and specificity is gained by using methods such as those mentioned above that directly assess functional impact specific to the gene and mutation of interest (Ng and Henikoff, 2001).
The availability of chemically unrelated mTOR inhibitors will be useful in confirming specificity of physiological responses observed when using these reagents.
These compounds will be useful for the specificity studies of many bacterial glycosyltransferases. Knowledge of the substrate specificities is the basis for the development of specific glycosyltransferase inhibitors that could block O-antigen biosynthesis.
The FRET peptide libraries provide an efficient and simple approach for detecting nanomolar concentrations of endopeptidases and are useful for initial specificity characterization as performed for two proteases secreted by a Bacillus subtilis.
In summary, we have reported the detailed expression pattern of a novel retinal marker with broad cell specificity, useful for retinal characterization in rodent experimental models.
Comparing cFA patients vs. carriers, and carriers vs controls gave similar results as for frataxin protein and did not reach a useful sensitivity and specificity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com