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Given the increased frequency of RTK mutations in MM, therapeutic intervention using RTK inhibitors could prove useful in subsets of MM patients.
Several studies have suggested that since "cladribine has a narrow spectrum of activity within the B-cell progeny" it may yet prove to be useful in subsets of patients with MM [ 16], because the self-renewing population of MM, arises at early B-cell precursors [ 17].
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Our finding that NPY positively correlated with perceived stress, anger, depression, negative thoughts and maladaptive coping in patients with CFS suggests that NPY will be useful in defining subsets of patients for clinical trials and as a measure of therapeutic effects.
This approach should also prove useful in identifying subsets of mRNAs that are regulated post-transcriptionally by changes in pre-mRNA splicing or 3' polyadenylation states [33], [60], [61], [62].
In our study, detection of serum p53 antibodies in non-small cell lung cancer patients has been shown to be useful in identifying subsets of patients with poor prognosis.
We believe that this approach could be particularly useful in specific subsets of patients with diabetes with unknown CAD and equivocal or uninterpretable stress tests or in case of a discrepancy between clinical presentation and stress test results.
A drug may be only useful in particular subsets of at-risk patients, with the DPP, as an example, showing a particularly great effect of metformin in patients who were younger and had higher BMI or fasting glucose levels at baseline.
COPA is particularly useful to determine differences in expression for particular genes in subsets of primary tumor samples, with improved performance compared to statistical tools that rely on median or average expression difference between two datasets [14].
We propose that combined EGFR and mTOR inhibitors may be useful in the subset of RCCs with wt-VHL.
This study demonstrated that preoperative imatinib may be useful in a subset of patients with initially surgically unresectable GISTs.
The authors concluded that Ga-BZH3 may be diagnostically useful in a subset of patients with GIST in whom viable tumour is suspected but F-FDG is negative.
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