The RF tests are mostly used without a clinically useful cut-off point based on predefined specificity, however, and thus true comparisons of results obtained with this test in different studies are not possible.
In order to determine the most useful cut-off for the CRP quotient the performance characteristics were calculated for measurements that were either normal or raised (CRP quotient >1× upper limit of normal [ULN]), and either greater than or less than 2.5×, 5× and 10× ULN.
The most useful cut-off values were calculated by identification of the highest score for sensitivity and specificity.
TLC, BMI, and HGB were treated as dichotomous variables at clinically useful cut-off points as described elsewhere [ 13, 14].
In every case, such data did not challenge the standard specifications iterated from the included studies, suggesting this was a valid and useful cut-off point to incorporate.
There is support in the published literature for this type of interpretation and a mean difference of 0.5 being a useful cut-off [ 1, 2].
A larger study is necessary to investigate if a clinically useful cut-off value for SAA in sepsis (with higher sensitivity and specificity) can be established.
When sensitivity in the model was set at 90%, a clinically useful cut-off point, the specificity was only 50%, correctly classifying only 58% of patients.
Objectives To assess and compare the cost effectiveness of three different strategies for prenatal screening for Down's syndrome (integrated test, sequential screening, and contingent screenings) and to determine the most useful cut-off values for risk.
In our analysis of multiple cut-off points (between 0.4 and 1.4 m/s) we found that between 0.8 and 0.9 m/s is the most useful cut-off above which frailty can be ruled out.
