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These signatures can then be used to predict function or functionally important residues of a novel protein.
Previous studies have shown that genes with similar expression profiles are functionally related; moreover, co-expression has been reasonably successfully used to predict function of unknown genes [8], [27].
Finally, co-expressed genes have been used to predict function of previously uncharacterized genes [5].
In some cases, a structural similarity remains over long evolutionary time scales and once detected can be used to predict function.
All genes that had a significant probe hit were aligned using CLUSTAL and the resulting set was then collected and Hidden Markov Models [22] were used to predict function with the Interpro scan program.
The annotation model was used to predict function similarities between proteins of interest and the data sets of proteins with gold-standard annotations in our training and test sets.
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In combining protein interaction network, highly connected coding genes linked by a given lncRNA were subsequently used to predict functions of the lncRNA through functional enrichment.
Such analyses have been used to predict functions of unknown genes based on coregulation with functionally known genes and for the identification of target genes of transcriptional regulators.
A common aim of high throughput gene expression studies is to identify genes with similar expression profiles since such genes may be functionally related and thus may be used to predict functions of unknown genes.
The functional profile of a phenotype might also be used to predict functions for uncharacterized genes and proteins implicated in this phenotype.
Top thirty biological processes enriched by 435 ranked positional candidates Network motifs that are the indicators of specific functional modules in cellular networks [ 12, 13] were used to predict functions for hypothetical HWEc genes.
More suggestions(15)
used to modulate function
used to predict water
used to predict behavior
used to predict efficiency
used to assess function
used to augment function
used to deduce function
used to analyze function
used to predict stress
used to perform function
used to evaluate function
used to compute function
used to measure function
used to indicate function
used to restore function
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