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The main nanotechnology processes used to make functional objects are described.
This chapter discusses the materials used to make functional electrical stimulation devices, including implantable pacemakers, defibrillators, and neurostimulators.
The DCN of the relevant species was used to make functional prediction for the query protein.
SIFT, Polyphen2, LRT, MutationTaster, and MutationAssessor were used to make functional prediction of missense variants [ 22].
Conservation of a gene in an operon is thus a strong indication of functional neighborhood and can be used to make functional inferences (Overbeek et al. 1999; Moreno-Hagelsieb and Janga 2008).
The model can be used to make functional predictions, e.g., heat shock response in isolated chloroplasts and changes of gene transcription levels under knockout of different σ-subunits or RNA polymerases or due to gene expression regulation.
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MapMan 3.5.1R2 [ 42] was used to make a functional classification of the proteins.
Additionally, phylogenetic approaches have been used to make general functional predictions for transcription factors for the AraC family [ 30].
Gene regulation takes place during transcription, the process by which the cell reads the information contained in a gene and copies it to the messenger RNA which is subsequently used to make a functional protein.
Lastly, the models can be used to make predictions about functional evolution in the absence of actual functional data.
Phylogenetic distribution profiles, physical clustering, gene fusion, co-expression profiles, structural information and other genomic or post-genomic derived associations can be now used to make very strong functional hypotheses.
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