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Repetitive transcranial magnetic stimulation (rTMS) was used to disrupt function in the right cerebellum, a region implicated in language [8].
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As mentioned, we predict that the anti-sense approach we have used to disrupt Rhox gene function is likely to affect all paralogues.
These results suggest that FI-peptide can be used to disrupt the ClpQY functioning in parasites and study functional significance of this protease machinery.
Previously, a dominant negative strategy with cardiac-specific overexpression of the VASP-EVH1 domain was used to disrupt the in vivo function of Mena and VASP [ 35].
In forward genetics approaches, many agents, including chemicals, radiation and viruses, are used to disrupt genes to identify their functions and the diseases associated with them.
On occasion, criminal prosecution is used to disrupt intelligence activities.
To identify developmental functions of Boc in the mouse, gene targeting in embryonic stem (ES) cells was used to disrupt the Boc gene.
Homologous recombination was used to disrupt a single MET6 gene.
A similar strategy was used to disrupt the TOF1 gene.
Although loss of any of the Elongator subunits is sufficient to disrupt function of the complex13, we used an Ikbkap/Elp1 knockout, because mutations in the human gene cause FD23.
These consequences are predicted to disrupt function of SEDLIN/TRAPPC2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com