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In the latter indication, metabolic imaging-based assessment of response has already been used to develop trial designs aimed to tailor treatments according to the level of efficacy [ 19, 20].
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18 Since then, a KPS score of >70 has been the cornerstone used to develop clinical trials for elderly glioblastoma patients.
Therefore, our results must be interpreted with caution and should be used to develop hypotheses for a larger trial combining qualitative and quantitative research.
Data from these analyses as well as evidence from the Prostate Cancer Prevention Trial were used to develop the schema of SELECT.
The tamoxifen-treated ER-positive, node-negative cohort from the Stockholm trial was used to develop the BCI algorithm.
Results from the EMPHASIS-HF trial were used to develop a discrete-event simulation model estimating lifetime direct costs and effects (life years and quality-adjusted life years (QALYs) gained) of the addition of eplerenone to standard care among patients with chronic systolic HF and mild symptoms.
The evaluated trials were used to develop a practice guideline.
Preclinical and clinical studies of panitumumab support the concept that hypothesis-generating molecular analyses can be used to develop retrospective studies that inform prospective trials on the use of tumour biomarkers, to predict response to targeted anti-cancer treatment.
Data from randomized trial I were used to develop the OBAS (factor analysis).
However, the measures of vision available in the clinical trial data sets used to develop the MSFC were limited to non-standardized tests of HCVA (Rudick et al., 1996, 1997).
Results of these trials can be used to develop clinical decision rules.
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