BSO is a selective inhibitor of γ-GCS, a key enzyme in the GSH biosynthetic pathway, and it is frequently used to decrease GSH levels in mammals [55] [58].
Traditional interventions, such as plasmapheresis and intravenous immunoglobulin (IVIG), are used to decrease antibody levels and inhibit antibody function, respectively (94, 95).
16 Some evidence also supports a decrease in the incidence of LTLS, CTLS, AKI, need for RRT, ICU admissions, and hospital/ICU LOS when rasburicase is used to decrease PUA levels in patients at high risk for TLS.
Secondly, this information is used to decrease the level of uncertainty in the rest of the system, which leads to improvement of accuracy of the set-membership estimates generated by an interval observer.
In the latter study, antisense molecules targeted to the initiation codon of PLP were used to decrease the level of PLP expression.
A Tet-On expression system was used to decrease the basal levels of TNF-promoter induced gene expression.
Metformin is a biguanide widely used to decrease plasma glucose levels by increasing intracellular glucose uptake (Bailey and Turner, 1996).
Population studies have shown that this biguanide, conventionally used to decrease peripheral glucose levels and increase insulin sensitivity in diabetic and pre-diabetic patients [ 11, 12], reduced breast cancer occurrence in female patients with type 2 diabetes [ 13].
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used to decrease hemorrhage below the level of aortic occlusion (AO); however, the amount of collateral blood flow below the level of occlusion is unknown.
Centrifugal pendulum vibration absorber (CPVA) systems are used to decrease steady state torsional vibration levels and extend operating ranges for rotating and reciprocating machinery.
