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Constitutive pol II promoters, such as CMV [ 6, 7] or UbC [ 8], have also been used (reviewed in [ 9]).
To test for QT prolongation already in pre-clinical settings, several cell and tissue models are currently used (reviewed in Joshi et al. 2004).
To overcome this problem, the use of stress-inducible promoters to control the expression of the ERF genes has been successfully used (reviewed in [ 21 ]).
We used reviewed diagnosis for the analysis as it has been shown to be prognostically better than initial routine diagnosis [ 12].
Among these, mouse mammary tumour virus promoter/enhancer (MMTV-LTR) has been most used (reviewed in [ 1]), since this promoter provides expression of a gene of interest in the mammary epithelium in both non-lactating and lactating females.
Studies of Dectin-1 knockout mice revealed increased susceptibility to gastrointestinal colonization with C. albicans and varying susceptibility to disseminated candidiasis, depending on the strain of Candida used (reviewed in [ 56]).
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