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When you throw in all of the many mouse-specific technologies people have developed over past years, it's not hard to understand why mice are the most commonly used model to study human disease.
The human monocyte cell line THP-1 can differentiate into macrophages after phorbol-12-myristate acetate (PMA) stimulation, which is regarded as a widely used model to study macrophage function [30, 31].
Therefore, the combination of the light-dye model with the exposure of vessels to ferric chloride for thrombosis induction represents a common and widely used model to study, in particular, molecular and cellular mechanisms of microvascular thrombus formation [21 23] and to study the association between inflammation and thrombosis.
PC formation can be induced in vitro in both fibroblasts and RPE1 cells, a widely used model to study ciliogenesis, by growing cells to confluence and this process can be enhanced upon serum starvation (see methods).
A widely used model to study epithelial regeneration of the bronchioles is naphthalene injury.
It is still the most widely used model to study the systemically infection of leptospirosis.
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Currently, the most widely used models to study NAFLD are genetically altered rodent models, e.g. the obese ob/ob mouse and fa/fa rat.
Jackson [ 56, 57], and later Ideta et al. [ 58], used models to study selection for androgen independent strains following androgen ablation in aggressive prostate cancers.
We used modelling to study the combination of TRAIL and LY303511, towards understanding their synergy and also aiding in the discovery of an unknown effect of LY303511.
In the next sections we review the most frequently used models to study the immunopathogenesis as well as some promising systems for evaluation of novel therapies.
Economists use models to study how individuals, businesses, and governments deal with choice.
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