Sentence examples for used gain of from inspiring English sources

As described in detail above, previous in vitro work in multiple cell culture systems has used gain of function (overexpression) and loss of function (RNAi knock-down) to demonstrate that NRP1 is essential for the proper presentation, recycling and degradation of VEGFR2.

To investigate the functional role of cHES6-1 durineurogenesissis, we used gain-of-function studies in the chick embryo, by ectopically expressing the protein in the spinal cord neuroepithelium.

To test whether Delg is functionally linked to any of these pathways, we used gain-of-function to induce overgrowth in clones in a wild type or a delg mutant background.

To investigate the role of MnSOD in ovarian carcinoma cells, we used gain-of-function and loss-of-function strategies.

The physiological relevance of HF-related microRNAs on the expression of putative gene targets was further established by using gain-of-function assays in two human cardiac-derived cells.

Our data, using gain-of-function analysis of ES cells, suggest that Pitx3 may be important for specification and/or maintenance of A9-like neuronal properties, while Nurr1 influences overall midbrain DA specification.

The role of VMHdm in defensive behavior has also been investigated previously using gain-of-function manipulations such as electrical or pharmacologic activation.

Furthermore, the enhancement of Plo1 localisation to the mitotic SPB using gain-of-function cut12.s11 is sufficient to suppress the pcp1-18 mutant.

Using gain-of-function and loss-of-function approaches we confirmed that DCD acts as a growth and survival-promoting factor in breast cancer.

Independent support for the role of Smarca1 in neuronal differentiation was obtained using gain-of-function experiments in mouse epiblast stem cells.

We subsequently focused on ULK1 to study autophagy using gain-of-function and loss-of-function assays as ULK2 upregulation by p53 remains complex in different cell lines under different treatment conditions (Supplementary Figure 5 and 6B).