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When the historical cohort was used for validation, the AUCs were lower, ranging from 0.61 to 0.68.
Based on the genotyped samples used for validation, the number of polymorphic SNPs ranged between 127,958 to 473,077 per commercial line.
Regardless of the type of MO used for validation, the purpose of this experiment is to determine whether the resulting phenotypes overlap, as would be expected for independent MOs targeted to the same gene.
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Preliminary simulations were used for validation of the algorithms and the optimal selection of the number of integration points.
55 The H-reflex tests will be used for validation of the MMAS and the MTS.
The RNA samples used for validation were the same as in the microarray experiments.
In each case this ~ 10% of the compounds were used for validation of the QSAR predictive models developed using the remaining 90% data during the training/testing [27].
The models were trained on 1 year, and then used for validation on the data from the next year by performing simulated trading.
The first probe (X'R'X'R'X') was used for validation of the reaction mechanism, in which the three complements are separated from each other by a recognition site (R') for PspGI.
Linear regression and ANOVA tests were used for validation of the model and the comparison of averages, respectively.
In addition, this dataset also includes exome sequencing data used for validation of the performance of the pipeline (see below).
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