Sentence examples for used for target validation from inspiring English sources

The method called Intracellular Antibody Capture (IAC) has been used to develop inhibitory anti-RAS and anti-LMO2 single domains that have been used for target validation of these antigens in pre-clinical cancer models and illustrate the efficacy of the IAC approach to generation of drug surrogates.

A luciferase reporter assay was used for target validation.

A chemical proteomic approach [ 4] has identified new protein targets for imatinib, and a similar strategy has recently been used for target validation of the broader TKI dasatinib [ 5].

Three cases each of CIN III (CIN III A, CIN III B and CIN III C) and normal cervical tissue (NA, NB and NC) which were used for target validation through real-time PCR were also collected, assessed and stored in the same manner.

Most of the gene-expressed RNAi libraries used for target identification and validation have been produced using computer algorithms and previously known genes or gene families.

This improved model can be used for drug target validation and development of new therapeutic strategies against breast cancer metastasis formation.

(1) As a result, their use as a tool for target validation, genetic studies, and for therapy of diseases that are rooted in aberrant gene expression, such as cancer, has become increasingly popular.

This is achieved by combining academic and industrial efforts to create open-access chemical and clinical probes [12] [14] which might be used in a pre-competitive manner for target validation purposes, for example.

The use of RNA interference (RNAi) for target validation allows the effect of gene knockdown on proliferation to be rapidly assessed ; however, these reagents might not always lead to sufficient mRNA knockdown to evoke a phenotypic effect.

These data are a valuable resource for target validation studies.

The mouse is also a better model for target validation.