Negative ICCs were truncated at zero because it has been suggested that negative ICCs should not be used for sample size calculation in CRTs [ 2].
Proportional sampling was used for sample size determination using formula proposed by Yamane (1967).
Test-retest metrics that are directly derived from the random ANOVA model (WSCV, ICC, and RC) can be also used for sample size calculation when planning a study that involves multiple PET scans per subject.
If blind variance estimators of the internal pilot are used for sample size recalculation and randomization test is used to accomplish the final hypothesis test, not only the blindness of the internal pilot is preserved but also the ability to control the type I error rate is guaranteed.
The intra-participant variability estimates of Cmax and AUC for oral diazoxide are not available in the published literature or from accessible unpublished studies; thus, an adaptive, two-stage sequential design (Potvin's method C) was used for sample size and power estimation.
For example, for a pre-post study design, within-subject standard deviation obtained from a test-retest experiment may be used for sample size calculation given an assumed effect size (mean difference between pre- and post- periods) as shown in [28].
The primary endpoint used for sample size calculation was Pfs25 QT-NASBA gametocyte prevalence after treatment.
STATA 10 is used for sample size and power calculations.
G*Power 3 was used for sample size calculations.
This table should not be used for sample size calculations.
This value is the inflation factor [ 4], used for sample size calculation in cluster randomized trials.
