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Most of the lower doses have been used for reversal of anticoagulation and intracranial bleeds [ 28, 33].
We compared J147 to donepezil in the scopolamine-induced memory impairment model using the same cognitive behavioral assays that were used for reversal of memory impairment in old AD mice.
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Warfarin causes a functional deficit of factors II, VII, IX, and X, as well as proteins C and S. Plasma should only be used for the reversal of warfarin if there is evidence of severe bleeding or intracranial haemorrhage.
It is therefore of potential clinical importance that this study also suggests that PCC and aPCC could potentially be used for emergency reversal of dabigatran.
Therefore, if using atipamezole for reversal of KX anaesthesia in rats, it has to be considered which is the most suitable moment for the administration in this species.
In practice, however, the estimates of reversals on terminal branches can be used for extrapolation of reversals on the branches emitting from the analyzed trifurcation.
Neostigmine was chosen as the comparator reversal agent as it is commonly used for NMB reversal in many countries.
These concentrates have largely been superseded in this setting by high-purity, plasma-derived factor IX and, more recently, recombinant factor IX and bypassing agents such as activated PCC and recombinant activated factor VII. Today, PCCs are mainly used for the emergency reversal of oral vitamin K antagonist (VKA) therapy [ 2, 3], although in the USA they are only approved for haemophilia.
Co-administration of vitamin K is recommended when PCCs are used for anticoagulation reversal [ 2].
To use a new vasovasostomy technique for reversal of vasectomy.
This paper describes a parametric study of a catalytic flow reversal reactor used for the combustion of lean methane in air mixtures.
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