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Determination of CAC can be used for reclassification of persons with moderate stroke risk (10 20%) Beyond this, patients with low-risk having a 10-year-risk below 10% have no benefit of this risk stratification.
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The methods used for evaluation included: i) reclassification of codes by four independent raters; ii) evaluation of trends over time in the use of medical codes for stroke; and iii) evaluation of one year mortality for groups of subjects with different index medical codes for stroke.
The R packages nricens and PredictABEL were used for risk discrimination and reclassification analyses.
Reclassification analyses (net reclassification improvement (NRI), integrated discrimination improvement (IDI), and category-free net reclassification improvement (cfNRI)) were used for the characterization of improvement of standard TIMI and GRACE risk scores by the addition of new markers and for the comparison of multivariate models with and without PTX3.
The net reclassification improvement (NRI) was used for evaluating the classification improvement of the biological parameters.
To assess model performance, cross-validation against data not used for model fitting was conducted and net reclassification improvement (NRI) was calculated.
The net reclassification improvement (NRI), produced by Penica et al., is used for evaluating the classification improvement when a new marker is put into a primary model [ 24].
Reclassification and cross validation error were re-estimated and gave similar classification performance compared to the 48 sample training sets used for the casework analyses, error estimates are given in supporting information Table S4.
We created the reclassification database using the methods described earlier, with the following improvements: more semantic classes were added, a much larger training corpus was used for the distributional classifier and many more concepts were reclassified.
We also examined model reclassification using the net reclassification index, NRI [ 21].
Now they say they're for it, but that Section 706 of the Act should be used instead of reclassification under Title II.
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