Thus it is critically important to have thorough characterization of the in vitro organoid system with regard to the extent of recapitulation of in vivo development before it is used for biomedical research and therapeutics.
It has also been claimed that certain former pieces of evidence for evolution which are now considered out-of-date and erroneous, such as Ernst Haeckel's 19th-century comparative drawings of embryos, used to illustrate his Recapitulation theory ("Ontogeny recapitulates Phylogeny"), were not merely errors but frauds.
Using expanded, redifferentiated costochondral cells in the self-assembling process allows for recapitulation of robust mechanical properties, and induced SZP expression, key characteristics of functional articular cartilage.
The plot, both too complicated and too inane for recapitulation, pits Armstrong — played winningly enough by Anthony Coleman — against corrupt and lecherous forces.
Mr. Ford's career is too well known to call for recapitulation.
For recapitulation to happen, an addition at the end of the original or ancestral developmental sequence or trajectory would have to occur (Fig. 4; Wägele 2005).
Orthotopic animal models provide the best fidelity for recapitulation of the tumor microenvironment, which are invaluable for cancer and drug development studies [ 16– 23].
In 3D cysts of cultured Madin Darby canine kidney (MDCK) cells, a well-established system for recapitulation of epithelial tube morphogenesis, PI 4,5 P2 is a key determinant of the apical membrane, where it is highly enriched (Martin-Belmonte et al., 2007).
Additional evidence for recapitulation of the earliest kidney differentiation stages in WT has been provided by molecular studies, exemplified by the WT1, IGF2 and other genes, implicated in nephrogenesis and associated with Wilms' tumorigenesis.
For recapitulation of the ces-D mutant phenotypes, a vector was constructed that allowed constitutive overexpression of CES under control of the 35S promoter in plants and conferred resistance to the antibiotic gentamycin.
