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Mean incidence and peak incidence were log-transformed to normalise the data; a logit transformation was used for outbreak size.
Moreover, the rapid sequence of events during the progress of the 2009 pandemic influenza revealed a functional gap between present methods used for outbreak detection and pandemic forecasting.
Each of these papers presents a classification of methods used for outbreak detection.
The ability to respond quickly and the measures used for outbreak detection and control varied.
Once these factors are identified, appropriate adjustments can be made to the quantitative methods being used for outbreak detection.
They are a powerful tool for evaluating the performance of surveillance systems and methods used for outbreak detection.
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Linkage by genotype required matching results by whichever genotyping methods were used for that outbreak (generally by spoligotype and either restriction fragment length polymorphism or 12-locus MIRU).
The first method uses the same person-to-person SEIR disease spread model as used for the outbreak spread pathway, but with different parameters, including large contact buffers, to produce a smaller number of cases which are not clustered in space.
The aim of this study was to describe the spatio-temporal distribution of the cholera outbreak in Papua New Guinea and highlight potential mitigation strategies that could be used for future outbreaks of cholera.
Moreover, the levels of pro-inflammatory cytokines observed for lpxL1 containing NOMV were similar of a similar magnitude to those induced by DOMV from wild-type bacteria, which are currently used for meningococcal outbreaks (data not shown).
Detergent extracted OMV vaccines have been successfully used for clonal outbreaks of meningococcal B disease (Martin et al., 1998; Dyet and Martin, 2005) but do not induce broad serogroup B coverage since the predominant bactericidal antibody response is against the major membrane protein PorA, which has high antigenic variability.
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