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Events were chosen (independent of the drugs) with the aim of generating a set which may be used for methods development on spontaneous reporting as well as EHRs.
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Pesticide standard solutions, individually or as mixes, were used for method development and instrument parameters optimization.
Drug-free rat hair, urine and serum samples were used for method development and validation.
Mass Hunter Data Acquisition Qualitativee and Quantitative analysis software (Agilent Technologies, Palo Alto, CA, v.B.06 and v.B.07) were used for method development, data acquisition and data processing for all the analyses.
Further, synthetic latent print reference pads were evaluated as mimics of natural fingermark residue to determine if the pads could be used for method development and quality control.
Waters' Acquity UPLC system (Waters, Milford, MA, USA) equipped with quaternary gradient pump, auto sampler, column oven, and photodiode array detector was used for method development and method validation.
There are several basic components to a liquid chromatographic (LC) system used for method development, and modern technology, from column chemistry to advanced detection and automation, is quickly changing the landscape of method development.
Certified calibration solution standards purchased from Sigma Aldrich and NRC-CNRC (Certified Reference Materials Program, Institute for Marine Biosciences, National Research Council of Canada) were used for method development, analyte identification and quantitation.
Skyline 2.1 was used for method development, data analysis and interpretation of the MRM results [ 79].
Analyst software version 1.5.2 was used for method development, data acquisition and data processing.
Skyline version 2.1 [ 90] was used for method development and optimization.
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