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The holdout dataset was then used for external validation of the model performance.
These three estradiol TDDS were used for internal validation whereas another two products of the same formulation design (with delivery rates of 60 and 100 μg/day) were used for external validation.
Another dataset consisting of 488 men previously treated with docetaxel (SPARC trial) was used for external validation.
Thus, the third group of GPS/leveling data, with independent 61 point-wise measurements, is used for external validation and the result is displayed in Fig. 12.
The leave one out cross validation (LOOCV) technique was used for external validation where N models were developed each with ((N-1)) chemicals as training set and 1 chemical as the test set.
Three hundred and fourteen eligible patients were identified and used for external validation analysis.
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EV1 dataset [ 15- 17] and EV2 dataset [ 18] were also used for external validations.
For this reason, data for conversions of 10 were excluded from the set during the establishment of the model and were used later for external validation.
One plausible reason why researchers choose not to use IPD for external validation is that they want to maximise the data available for model development; this is understandable, especially when faced with a large set of candidate predictors and possible non-linear relationships.
Vaseline is used for external use only.
A test set of 7 compounds was used for the external validation.
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