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Multiple linear regression (PROC REG in SAS 9.1) was used for continuous values of ABI and blood pressure, as a function of demographic variables, risk factors and disease markers.
For the clinical parameters, t-tests will be used for continuous values or the Mann-Whitney U-test when the variables are not normally distributed.
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Second, three-level linear regression models were used for continuous dependent variables (eg values of systolic blood pressure).
If no previous value was observed, the median population value was used for continuous variables, and categorical variables were imputed at the category with the highest proportion of observed values.
Last observation carried forward imputed values were used for continuous variables.
In descriptive statistics, numbers and percentages were used for discontinuous variables, mean ± standard deviation and minimum and maximum values were used for continuous variables.
148 were diagnosed by inclusion criterion 1, seven by inclusion criterion 2, eight by inclusion criterion 3 and two by inclusion criterion 4. a The bacterial aetiologies in the five cases with hydrocephalus were S. pneumoniae (3) and E. coli (2). a Median values are used for continuous variables.
When P values were adjusted for age, ANCOVA was used for continuous variables and logistic regression for categoric variables.
The pooled SMD or WMD was used for continuous outcomes.
Inferential statistics were applied comparing these two groups of mice using t-test for continuous values with normal distribution.
Measure S2 is calculated from the length (L) of the sequences by using the normalized difference for continuous values [ 40].
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