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12 rats received indomethacin 20 mg/kg, which is a commonly used dose to induce consistent small intestinal damage in the rat (characterized by mitochondrial damage on electron microscopy within an hour,[ 17] neutrophil infiltration of mucosa on light microscopy at 3 5 hours and macroscopic lesions (ulcers) at 12 18 hours [ 18]);.
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This implies a revision of the routinely used dose indexes to obtain quantities related to individual exposure evaluable from acquisition parameters.
We used dose titration to optimise the response and avoid excessive constipation.
Overall, five of the studies reviewed here used doses adjusted to achieve matching AUC (US studies) [1,7,16,19,23], five used 1 1 dosing [13,17,22,24,25], and three used other methods [14,20,30].
The present study used dose-addition analysis to evaluate CB1/NMDA receptor interactions on this endpoint.
Most reports have used doses of 2 to 10 million MSCs per kilogram in small animal experiments [11].
The investigators used dose-equivalent relationships to estimate the costs of intoxication.
Diabetic type 1 patients are often advised to use dose adjustment guidelines to calculate their doses of insulin.
Insulin dependent diabetic patients are often advised to use dose adjustment guidelines to calculate their doses of insulin for each self-administration.
No TEs attributable to CDP7657 (using doses up to 200 mg/kg i.v).v
Hegazy et al. demonstrated retinal toxicity to routinely used doses of intravitreal antibiotics in silicone oil-filled eyes.
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