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The corpus callosum was found to be metabolically stable in APPPS1-21 mice and was thus used as a reference region to normalize regional uptake values.
This complexity is compounded by recent data suggesting that [11C]--PHNO PET scans might be routinely performed in non-tracer conditions (with respect to D3 receptors), and that the cerebellum (used as a reference region) might manifest some displaceable binding signal.
The centrum semiovale was used as a reference region.
We also demonstrated that the binding ratio of 18 F-DPA-714 was higher when the contralateral VOI was used as a reference region, compared to when the cerebellum was used as a reference region.
Similarly to human studies, the CB has usually been used as a reference region in small animal amyloid imaging studies.
While the cerebellum was used as a reference region, some issues have risen questioning the validity of the cerebellum as a reference region.
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This issue can be minimized by using as large a reference region as possible, and with good sample preparation methods.
The extensive Cancer Genome Atlas Network (TCGA) work has been used as a reference for genomic regions frequently amplified/deleted as well as arm-level gains and losses (773 breast tumours), using reported data from basal-only and total breast cancers analyses [ 8]. miRNAs located on TEs, given their uncertain location were excluded from any analysis related to DNA copy numbers.
Tobacco chloroplast genome sequence was used as a reference and its coding regions were delineated in the aligned sequences.
AgrinC localizations in each region were fitted with a double Gaussian distribution, and the mid-position between the peaks was identified from each image and used as a reference to align subsequent regions.
More specific, not in all scans the whole cerebellum was scanned because of a skewed position of the head (the brain-dedicated system is a tomographic system), and consequently, this region could not be used as a reliable reference region [5].
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