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Intravenous bolus is the most frequently used administration protocol in small-animal imaging.
While antibiotic selection has been commonly used, administration of cytotoxic drugs often leads to deleterious effects not only to inert cells but also to transfected or transduced ones.
Anaesthetic dose rates for injectable agents will depend on species used, administration route, age, sex, strain, body condition, environment, experimental set-up, previous drug treatments and the level of anaesthesia required.
The concentration changes depending on the animal model, PTHrP fragments used, administration time, and so on.
Four different methods of drug administration were used: administration by volumetric pump, administration by syringe pump, administration by 'unaided' infusion bag, and administration by direct IV injection.
Clinical trials were excluded if they either used administration routes other than recommended or included no treatment arm with recommended doses.
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Catalytic scavengers are enzymes displaying a turnover with OPs as substrates, allowing rapid and efficient protection using administration of small doses.
experimental metastasis model using administration of NCI-H460 human lung cancer cells [9], [10].
Our findings suggest that PSIs could be used to screen potential cases with adverse events using administration data.
One approach, iontophoresis, uses administration of a low electrical current to actively drive diffusion of charged molecules across the stratum corneum without the need to increase skin permeability.
The findings from this phase 2 study have shown that darbepoetin alpha is effective compared with placebo using administration schedules as infrequent as every 4 weeks.
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