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We used a tissue array material consisting originally of 556 breast carcinomas as the target material of which 511 were invasive and 45 of in situ type.
In the present study, we used a tissue array composed of 27 BOVs, 78 LMPs and 23 LG TOVs to evaluate the protein expression of a subset of selected candidates identified in our previous studies (Ape1, Set, Ran, Ccne1 and Trail) or known to be implicated in epithelial ovarian cancer disease (p21, Ccnb1, Ckd1).
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We used a tissue arraying instrument (Beecher Instruments, Silver Spring, MD, USA) to punch triplicate 0.6-mm-diameter cylinders of tissue from selected cancer areas of individual donor tissue block and re-embed into a recipient paraffin block at a predefined position.
We tested the prognostic value of ALDH1 using a tissue array of serous ovarian cancers, the most common histotype of human epithelial ovarian cancer.
Tissue blocks were constructed using a tissue array (Minicore; Alphelys Impasse Paul Langevin, Plaisir, France).
We assessed expression of RUNX2 in a cohort of human breast cancers using a tissue array (TMA-1).
All TNBC cases (the 12 cases and the additional 36 cases using a tissue array) expressed MAS1.
Using a tissue array, we scored the staining intensity of more than 500 tissue samples that had 16 types of cancer together with non-malignant tissues.
Tissue biopsies of 0.6 mm diameter were taken from each donor block and mounted in a recipient block using a tissue array machine.
A recent study [ 7] done using a tissue array consisting of 372 primary breast cancer specimens found a 5% incidence of FGFR2 amplification.
A recent study [ 7] that was done using a tissue array consisting of 372 primary breast specimens found a 5% incidence of FGFR2 amplification.
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