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In line with the principles of quality by design (QbD), we used a statistical design of experiments (DoE) methodology to design the optimum process which delivered bioactive HBx at a productivity of 0.21 mg/ml/h at a refolding yield of 54% (at 10 mg/ml refolding concentration), which was 4.4-fold higher than that achieved in dilution refolding.
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We used a statistical design-of-experiments approach to identify angiopoietin interference in bridging immunoassays of anti-AMG 386 antibodies.
The proposed method was developed and optimized using a statistical design of experiment approach.
In this work, the CVD of BN was investigated using a statistical design of experiments (DOE) approach.
Here we use a statistical design of experiment approach to re-evaluate the composition spectrum of the 2xxx alloys.
The spray drying process was optimised using a statistical design of experiment and by evaluating powder characteristics upon systematic variation of the formulation parameters.
The effects of air flow rate, inlet air relative humidity and substrate initial moisture on endoglucanase production were evaluated using a statistical design methodology.
The proposed approach uses a Markov chain approach to compute the statistical performance, and uses a statistical design model to design DSVSI ¯¯¯X and s charts for detecting the mean shift and variance increase.
Statistical models established using a statistical design of experiments indicate that the W/C has greater effect on changes in minislump flow, washout, and RCS than the concentrations of HRWR and AWA.
These CPPs were prioritized using a process failure mode, effects, and criticality analysis and their critical impact on the CQAs was experimentally confirmed using a statistical design of experiments.
To this end the percentage of porosity as a function of both the amount of set-retarding admixture and the kneading water needed was assessed using a statistical design of experiments (DoE) approach.
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