Therefore, we used a mouse model of bone metastasis to assess global crosstalk between the hypoxia and TGF-β signaling pathways in vivo.
We tested the effect of HIF-1α knockdown in vivo using a mouse model of bone metastases.
Moreover, in PET study using a mouse model of bone metastasis, Ga-NOTA-BP showed high accumulation of radioactivity in osteolytic lesions in the tibia.
Using a mouse model of ectopic bone formation, HGF-impregnated gelatin sponges displayed significantly reduced bone formation induced by BMP-2, both radiologically and histologically.
This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1 −/−).
We show that RCAN1 is induced in human and mouse atherosclerotic tissues and, using a mouse model of atherosclerosis and bone-marrow (BM) transplantation assays, we demonstrate that Rcan1 in haematopoietic cells promotes atherosclerosis.
Hormones were measured as follows: PTH using a two-site ELISA kit (Immunotopics); insulin, glucagon, and leptin using a mouse endocrine multiplex immunoassay kit (Millipore); ACTH was quantified using the mouse bone panel kit (Millipore); and osteocalcin and total adiponectin using mouse singleplex immunoassay kits (Millipore).
We exclusively used primary mouse bone marrow-derived DCs (BMDCs) in the herein study.
Several authors [ 28, 29, 31, 32], used in mdx mouse, bone marrow cells for DMD treat.
As, to our knowledge, no DC cell line fully recapitulates all of the biological properties of primary DCs, we have conducted our study using primary mouse bone marrow-derived DCs (BMDCs) that were activated by E. coli LPS (referred to as "LPS" hereafter).
