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Firstly, we used a high threshold to define the occurrence of CHE.
Following the conservative approach above, we intentionally used a high threshold to sort out potential genotyping errors.
As we did not have sufficient studies that used a high threshold, we cannot determine the relevance of ambulatory monitoring in people with high clinic readings.
When we analyzed the determinants of catastrophic medical expenses, we used a high threshold of payments of at least 40% of a household's capacity of pay.
We used a high threshold of ≥ 8-fold difference in mRNA levels (measured as normalized averaged mapped sequence reads per gene from two datasets each for tachyzoites and merozoites) to identify stage-specifically regulated genes [ 9].
We used a high threshold level of genome-wide significance (i.e., 5.4 × 10 7) to protect against false-positive findings caused by multiple testing (O'Berg 1980; Risch and Merikangas 1996; Wolff et al. 1993).
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During the resuscitation phase of septic shock, a substantial number of clinicians may have used a higher threshold of hemoglobin at 10 g/dL, as recommended in the Surviving Sepsis Campaign Guideline 2008 [3].
One study did find increased incidence of hypokalemia after implementation of TGC, but this study used a higher threshold to define hypokalemia [ 24, 32].
The PPARγ binding sites are in general more narrow than C/EBPα, so we used a higher threshold of 10% overlap for PPARγ.
On the other hand, Viaud et al. used a higher threshold test of a urine protein to creatinine ratio greater than 0.5 mg/mg to define proteinuria and found a 54% incidence [ 46].
Post-hoc sensitivity analyses used a higher threshold for side effect definition of very or extremely bothered and removed "agitation" from the EPS/agitation cluster due to the potential confounding of agitation and restlessness associated with akathisia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com