We decided to use a fixed protocol to translate the test results into a management strategy with nifedipine, to out rule the influence of individual physicians.
The patient number is relatively small, antiemetic medications were not administered using a fixed protocol, antiemetic levels were not measured, and the triplicate ECGs were performed too far apart to permit exposure-response modeling.
Less commonly, it may be used to define a fixed protocol of options to follow as general guidelines.
The procedure was standardised with a fixed protocol using available literature and being critically analysed for each medication, giving the recommended dosages at normal and reduced renal function in per cent of normal dosage, prolonged dosage interval or both.
This initial assessment (T1) was followed by a 6-week adaptation period during which participants increased their daily use of the system according to a fixed protocol, so that by the end of the fourth week, all subjects were able to use the system for the entire day.
In Panama, a fixed protocol of 25 IU kg−1 3x/wask was used.
We also determined the effectiveness of steroids with a fixed protocol for bronchodilator use compared with those in which the bronchodilator was given at the discretion of the attending physician, and bronchodilators given with and without steroids.
It should also be recognized that monitoring iCa concentrations is not necessarily required because some protocols use a fixed relation between citrate and blood flow (summarized in [ 8]).
Some protocols use a fixed dose of citrate in relation to blood flow according to an algorithm, and target such doses at about 3 mmol citrate/l blood flow [ 37].
For competition ELISA performed with some positive sera, a similar protocol was engaged, using a fixed dilution of the sera and B-Raf or B-Raf V599E antigen for coating.
