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Trial-related NHS resource use will be estimated using the information from direct enquiries to the trial coordinators, and from a staff costs questionnaire (Additional file 9).
Unit costs for health service use will be estimated using data from the Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS), plus any additional OOP costs reported by participants.
23 Phone use will be estimated separately for mobile phones and DECT phones based on the question of how many minutes a person called in the interval between alarm cues: 1 5, 5 10, 10 20, 20 30, 30 60 or longer than 60 min.
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For example, healthcare use costs will be estimated using national Medicare reimbursement rates (average DRG rates) for hospitalization, Medicare fee schedules for physician and other professional services, and Medicare's Resource-Based Relative Value Scale (RBRVS) for outpatient procedures.
When more than one laboratory method was used, these will be estimated separately for results from both methods, for comparison with the first IID Study and as a baseline for the future.
Resources required in training individual patients to use HeLP-Diabetes will be estimated.
In this study, three commonly used responsiveness indices will be estimated.
Time and cost of data collection using these methods will be estimated.
As for clinical outcomes, missing resource use and QALY data will be estimated by multiple imputation.
The model will be estimated using maximum likelihood estimation.
For the cross validation, the predicted hazard rate will be estimated using 2STEP and the predicted phenotype will be estimated using LAM.
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