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This observation prompted us to use these cells to identify the signaling pathways involved in HSC proliferation.
Given the innate cancer-homing capabilities of MSCs, it may be possible to use these cells to treat CRPC with therapeutic gene delivery.
The hope is to use these cells to replace diseased myocardium that would otherwise progress to outright failure and regenerate the heart to its former, healthy self.
It seemed reasonable to use these cells to investigate the effects of developmental CSF without the confounding effects of age-dependent responses of primary cells.
However, how HIV-1 manipulates DC biology to use these cells to its own advantage without marked cytopathic effects is still unclear.
In summary, we have generated the first cell line that lacks SPAK and OSR1 catalytic activity and use these cells to demonstrate the vital role that SPAK/OSR1 play in regulating NKCC1 activity.
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Dr Mark Post and his team at Maastricht University used these cells to grow 20,000 muscle fibres in individual culture wells, each one a tiny hoop of greyish-white protein suspended in a gel-like growth medium that contained antibiotics and a serum extracted from cow foetuses.
Because A431 cells have been shown to express GPR87, we used these cells to examine whether GPR87 acted as an LPA receptor.
As T cells readily circulate through the body, using these cells to deliver OVs directly to tumors may provide an ideal combination.
We have used these cells to evaluate, using immunocytochemistry, reverse transcriptase-polymerase chain reaction, and Western blotting, direct effects of the glucocorticoid dexamethasone at concentrations designed to mimic in vivo therapeutic corticosteroid levels.
Collaborators at the University of California, Los Angeles, then used these cells to treat an elderly woman who has dry age-related macular degeneration and a woman in her 50s who has Stargardt macular dystrophy, a rare inherited disease.
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