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First, all manufacturers could use the same cohort of healthy individuals for the derivation of the respective 99th percentile of all clinical assays.
Furthermore, studies that use the same cohort to establish quantitative biomarker thresholds (cut-points) and assess their performance will be deemed as 'exploratory' unless appropriate cross-validation has been performed.
8 Here we use the same cohort, the Avon Longitudinal Study of Parents and Children ALSPACC), to investigate the fetal growth of offspring of smoking mothers only comparing the offspring of mothers and fathers who were themselves exposed to cigarette smoke in utero with those who were not exposed in this way.
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To assess the predictability of re-arrest from basic demographic data, namely, age, gender and race, we trained a simpler model using the same cohort and an elastic net model.
Thus, the validation of selected transcripts was done using the same cohort of eight subjects from the cocaine and control groups.
In the parent study using the same cohort of patients we show that unstimulated IFN-γ levels very accurately distinguishes TB from non-TB effusions in African patients (data not shown).
Significant downregulation (FWER<0.05) of genes in pathways representing OXPHOS and ribosomal proteins in PCOS patients was identified using both GenMAPP and GSEA, and, in part, validated our previous findings, where we used the same cohort of control subjects and 16 insulin resistant PCOS patients [16].
In the current study, using the same cohort and three additional control non-minocycline treated animals, we report minocycline treatment reduced activation of monocytes that inversely correlated with neuronal injury, reduced the accumulation of monocyte/macrophages in lymph nodes of treated animals, and inhibited the expression of CCR2, CD163, CD11b, and CD64 on monocytes.
Using the same cohort of children, we also estimated the proportion of children who escaped Pf blood-stage infection during the survey period and found no differences between A+/A− heterozygotes (27.3%) and A+/A+ homozygotes (22.5%) (log-rank test, p = 0.875; hazard ratio 1.051, 95% CI: 0.471, 2.420; Figure 1B).
(2012) using the same cohort of children.
We investigated the PES1 expression in each of the INSS stages using the same cohort.
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