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The excellent hydrogel adhesiveness and degradation behavior and preliminary efficacy in anti-adhesion in mouse model guided us to use the rat model which is commonly used in assessment of the efficiency of barrier devices [ 22].
We decided to use the rat model since it is the most commonly used animal model of myocardial infarction and heart failure and had convincingly been shown to mimick the mechanisms of human HF.
In the present study, there was an additional reason to use the rat model: contrary to the paucity of proteomic databases applicable to some other animals such as dogs and cats, the availability of the rat proteomic database would allow us to identify interesting proteins based on the MS results.
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Using the rat model, the present study demonstrates some limitations.
Finally, our findings may widen the scope for future studies of decision-making mechanisms in the context of social interactions [41], [42] using the rat model system.
These results collectively demonstrate for the first time, using the rat model, that IT vaccination with live subsp. novicida induces a potent cellular and humoral response and confers significant protection to subsequent pulmonary challenge with subsp. tularensis.
One previous study used the rat model [ 49], starting with the 6 hr time point.
We used the rat model of pain memory described by Igor Kissin [ 3].
As an in vivo model for studying the effect of these mutants after their extracellular application, we used the rat model of cerebral ischemia.
Both mouse and rat are accepted in swimming exercise protocols, in this view, we used the rat model precisely by fact that rats TGI exhibit more similarities to humans, being more sensitive to the cholinergic transmission [ 34, 35].
The objective of this study was to investigate the potential of green tea to reduce the bioavailability of methylmercury from a fish tissue meal using the rat model and compare it to the standard medical treatment for mercury chelation, DMSA.
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