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Analyses will follow Harrell's guidelines 78 and will use the multiple imputation procedure available in SAS SAS Inc , North Carolina, USA).
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Missing values were imputed using the multiple imputation option in SPSS 21.
Missing data will be imputed using the multiple imputation routines in STATA v11.
Missing data will be imputed using the multiple imputation routines in STATA version 11.0 [ 57].
If judged appropriate, missing data will be imputed, using the multiple imputation facilities available in R (http://www.r-project.org/).org/
If judged appropriate, missing data will be imputed using the multiple imputation facilities (eg, mice in R).
Missing data will be imputed using the multiple imputation function as provided in SPSS 21 (IBM Corp, Armonk, NY, USA).
All other missing values for covariates were imputed using the multiple imputation by chained equations method [ 25].
Primary and secondary analyses will be based on the intension-to-treat (ITT) principle, and the missing data will be imputed using the multiple imputation method.
If judged appropriate, missing data will be imputed using the multiple imputation facilities (mice package) available in R (http://www.r-project.org/).org/
Missing cost data, for example, from patients who did not consent to access to their MBS, PBS, and public hospital data will be imputed using the Multiple Imputation using Chained Equations (MICE) approach.
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