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As a similar well-characterized rat promoter fragment was not available and the cross-species use of promoters to express tet controlled transactivators between rats and mice has been successful in the past [ 18- 20], we decided to use the functionally proven mouse CaMKIIα promoter to spatially control tTA expression in transgenic rats.
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Using the functionally intact TG2/eGFP, we visualized the subcellular distribution of TG2 first in HEK/293T cells and subsequently in SMCs.
These results were confirmed by breadth-first traversing this network using the functionally characterized Sge1, Vba1, Vba4, Arn1, Arn3, Arn4, Gex1 and Knq1 proteins as starting nodes.
Though Myc is expressed in type B spermatogonia and early prophase spermatocytes (Wolfes et al., 1989), JQ1 exposure did not suppress the expression of MYC target genes, as assessed by GSEA using the functionally defined MYC signature validated by Dang and colleagues (Zeller et al., 2003).
For clarity, here we refer to this (and other) discrete RNAs using the functionally-descriptive name of 'Xrn1-resistant RNAs' (xrRNAs) in order to distinguish them from the longer sfRNAs.
We also use the notion functionally annotated.
But if everybody is using the same functionally functional localizer to identify a region and then to say something about it, then we can all build on each other's results and have scientific nirvana where we actually get somewhere, right?
When the activities of daily living, ability to functionally use the arm, range of motion, pain, strength, are separately considered, outcomes may be different as they depend on age, gender, cultural level and job.
I did not use the results to predict functionally important sites in the viral data sets, but the forward-backward algorithm can compute the most likely unobserved state, diverged or not, of each nucleotide site [ 76].
To explore the relationship between VBM lesions and network hubs in a different (functional) network, we used the network of functionally co-activated brain regions, as previously reported in detail (Crossley et al., 2013).
Results indicated that interventions matched using the SIM Form were functionally related to improved student outcomes across a variety of dependent variables when compared to mismatched phases.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com