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This chapter provides examples of clinical trials that use the endpoint, time to progression, and discloses the advantages (and disadvantages) of using this particular parameter as an endpoint in oncology clinical trials.
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The present study used the endpoint of hypothermia to investigate opioid and neuropeptide FF (NPFF) interactions in conscious animals.
We obtained a qualitatively similar result using the endpoint of baseline FEV1/FVC ratio, although the relationship was not statistically significant.
SWCNT were routinely tested for bacterial endotoxin (LPS) contamination using the endpoint chromogenic LAL method, as previously described [31].
The reaction tube was incubated at 65°C and samples were transferred to ice and remaining activity was measured using the endpoint assay.
Titers were determined by using the endpoint method (33 ).
Genotypes were assigned using the endpoint genotyping analysis software.
All assays with T3Δ1.3AE used the endpoint population; all assays with T3Δ1.3BE used an isolate from the endpoint population.
Serum endotoxin (LPS) concentrations were analyzed using the endpoint chromogenic limulus amebocyte lysate (LAL) assay (Lonza, Switzerland).
As shown in Table 3, 11 of these used the endpoint "snuff-dipper's lesion" as defined by Axéll et al [ 15] and a further three used an endpoint which appeared to be similar.
The degree of error can be up to 57% [ 16], but modern auto-analyzers using the endpoint Jaffe method have overcome such interference.
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