We recorded the use of chemotherapy (yes or no), tamoxifen (yes or no), and radiotherapy (yes or no).
We also examined whether the associations between alcohol and cancer differed by age (<65 years v ≥65 years), body mass index (<25 v ≥25), family history of colorectal cancer or female breast cancer (yes v no), current use of multivitamin (yes v no), regular use of aspirin (yes v no), dietary adherence to AHEI 2010 (median value or over v less than median value), and smoking history (never v ever).
Sex, age, duration of diabetes, arterial hypertension status (yes or no), use of diuretics (yes or no), HbA1c, triglycerides, HDL cholesterol, eGFR, UAE, and copeptin (tertiles) at baseline were entered as independent covariates.
These differences remained significant after additional adjustment for the duration of diabetes, HbA1c, triglycerides, HDL cholesterol, UAE, arterial hypertension status (yes or no), and use of diuretics (yes or no) at baseline (P = 0.003 for the whole population and P = 0.03 for the subjects with microalbuminuria).
Potential confounders included: BMI (continuous variable), age at menarche (continuous variable), age at menopause (continuous variable), previous use of OCs (yes, no), previous use of HRT (yes, no), smoking (never, past, current), and physical activity (inactive, moderately inactive, moderately active, active).
bcoding: 'problems with (the use of) …' yes = 1, no = 0.
Use of contraception (yes versus no, P = 0.10).
Also collected were use of insulin (yes or no), BMI, number of complications, and number of comorbidities.
We also adjusted for the prostate specific antigen test (yes v no) among men, and menopause status (premenopause or postmenopause), postmenopausal hormone use (never, past, or current), and use of mammograms (yes v no) among women.
Similar distributions of OS according to EGFR status were also observed when the survival analysis was adjusted for the use of docetaxel (yes or no; p = 0.390) and the type of platinum used (oxaliplatin or cisplatin; p = 0.337).
