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Recent studies have described the use of transcript abundance data from RNA hybridizations to Affymetrix microarrays to discover genetic polymorphisms that can be utilized as markers for genotyping in mapping populations (Borevitz and Chory 2004; Gupta et al. 2008; Hazen and Kay 2003; Shiu and Borevitz 2008; Zhu and Salmeron 2007).
Approval included the use of transcript data in study reports and publications.
Another use of transcript sequence is in annotation, a key to the utility of whole genome sequencing.
This has been made possible through the development of novel methods that make use of transcript expression profiles.
Here we report the use of transcript clustering to identify molecular mechanisms contributing to early stages of AD in mice.
With the use of transcript pattern approach, therefore, the observed difference in fold-change magnitude across platforms should largely be attributed to the differences in array inherent characteristics.
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The use of transcript-derived SNPs will greatly facilitate the investigation of the putative gene content in the QTL-harboring regions, eventually leading to a more rapid identification of candidate genes at least for those cases where direct links between the putative gene function and the phenotype can be established.
The use of transcripts as a diagnostic tool for biotechnological applications has been proposed previously [ 8, 11, 45].
Recall and accuracy were studied extensively through the use of transcripts, which were transcribed verbatim, and coding according to an extensive coding schedule.
Use of the transcript pattern enables more of an "apples-to-apples" comparison and reduces potential transcript signal bias as a confounding factor to the analysis and interpretation.
The rabbi's lawyer, Michael E. Riley, had no legal grounds to challenge the use of the transcript and had no way to rebut the portions of old testimony Mr. Lynch considered favorable to his case.
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