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The use of this methodological approach illustrates how traditional, microarray-based gene expression data can be integrated with a novel TF-gene interaction database generated from primary genome sequence analysis to reveal higher-order, cell-specific transcriptional regulatory networks.
We made use of this methodological resource, with the exact intention of under-representing samples from centres with a smaller population, since otherwise it would be more costly in resources and time to reach those centres, which would then lead to a different weighting of results to take this additional imbalance into account.
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– use of the methodological tools available as outlined in this paper.
Secondly, the consistent use of the methodological framework, potentially contributed to the emphasis on, and the potential recognition of, similar capacity issues.
To review the use and usefulness of the methodological strategy of triangulation in the assessment of skill in nursing curricula.
This may be partly explained by the use of different methodological tools and assumptions by their authors.
This outcome measure was developed through the use of a methodological approach that began not from existing constructs but rather by listening to the experiences of individuals who had undergone CAM treatment.
A quick search of MEDLINE (via PubMed) using the key word "AMSTAR" on 14 March 2015 retrieved 200 documents, most of which described the use of this checklist to evaluate the methodological quality of SRs published in a great variety of medical disciplines.
However, we draw more detailed and valid conclusions due to our use of improved methodological rigor.
Nevertheless, since the focus is on illustrating the use of a methodological novelty in studying food safety, using data from 2005 is still informative and insightful.
To facilitate the optimal use of PGHD, methodological research around considerations related to feasibility, validation, measure selection, and modeling of PGHD streams is needed.
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