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The use of these formulas in this way shows potential, especially if used with a mobile phone app, and requires further investigation.
Two arguments can be made to justify the use of these formulas.
Unfortunately, the restricted use of these formulas for specific creatinine methods has not been an overriding concern in some studies.
Traditional medicine in Asian countries commonly combines herbs to create multi-herbal formulas for treating target diseases, and the use of these formulas has been verified scientifically as complementary or alternative cancer therapies [ 16].
Amino acid-based formulas (AAF) can alleviate diarrhea due to food allergies [ 5, 6], although, there is a paucity of evidence regarding the use of these formulas to treat pediatric patients with other forms of CD.
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Therefore, the use of these formulae has advantages over an approach involving the direct calculation of the volume integral using Eq. (7).
Finally, we include an example that employs the multiple matching study design about the use of the supplemental ascorbate in the supportive treatment of terminal cancer patients to illustrate the use of these formulae.
Recent work conducted in Europe, as part of the HYDRATE research project and other studies, has shown that the use of these formulae and their associated tabulated roughness values available in current guidance documents, without further verification, can lead to over-estimates of peak discharges in the case of flash floods.
The caveats associated with the use of these formulae in cancer patients have previously been discussed [ 21].
If the reader wants to try these formulas with a different set of data, we have provided an Excel spreadsheet file with the formulas at In this section we will discuss the use of these estimating formulas on the effect size for the meta-analysts.
The most commonly used of these formulae to predict creatinine clearance, and hence GFR, in adult patients have been those published by Cockcroft and Gault and that of Jelliffe, using age, sex, serum creatinine and either body weight (Cockcroft and Gault) or surface area (Jelliffe) as a measure of body size.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com