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Fully informed consent means that the person should have access to all information relating to the use of the specimen provided.
The collection and use of the specimen have been approved by the Human Research Ethic Committee of the University of Hong Kong.
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The use of the specimens for construction of the TMA and subsequent biomarker molecular pathway analysis was approved by the Children's National Medical Center IRB and the Armed Forces Institute of Pathology IRB.
Ethical approval was obtained from the Stockholm South ethical committee (Dnr 238/02) for use of the specimens from the Karolinska Hospital Huddinge, and from St Louis University, USA (number 12968), for use of the samples provided from healthy individuals.
Approval for use of the specimens was given by the TREAT in JIA study oversight committee.
Approval for use of the specimens was given by the TREAT study oversight committee.
Use of the specimens for the purpose of the present study was approved by the ethical commission of Kantonsspital Basel.
The study was approved by the Ethics Committee of Tokyo University Hospital and patients gave their written informed consent for the use of the specimens in advance.
The use of the specimens and data for research purposes was approved by local laws (HmbKHG, §12,1) and the local ethics committee (Ethics commission Ärztekammer Hamburg, WF-049/09 and PV3652).
In each case the individual patient consents have been written as broad tissue banking protocols, thus ensuring a uniform approval for the use of the specimens in multiple types of research studies.
Especially, the use of this specimen in the frame of ISO standardisation for optical instruments is indicated.
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