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This study made use of the prospective prion disease surveillance in Japan to analyse clinical manifestations of dCJD cases taking into account not only their grafting sites but also their pathological subtypes.
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However, activation of the complement system, a complex innate immune network of over 30 circulating and membrane-bound proteins, remains a serious concern related to the use of these prospective neurological nanomedicines.
Therefore, in this study FDG-PET will be used for the prospective evaluation of tumor response after PT/HIT.
As a result, a key recommendation that has emerged is the use of the PRoBE (prospective-specimen collection, with retrospective-blinded evaluation) design for biomarker discovery and validation [29].
The 199 differentially expressed proteins selected by ANOVA using the primary data set were used for classification of the prospective data set.
The large sample size and the use of a prospective design in the collection of data to assess guideline adherence constitute the strong points of this study.
Participants will be educated in the use of the study-specific prospective SMBG hypoglycaemia diary.
The major strength of the study is the use of a prospective cohort design.
The use of such prospective measures enable the conservation and focus of valuable human and financial resources, which in some cases could be the difference in making an otherwise chaotic epidemic situation tractable.
Using the envelope of the prospective randomized trial, we conducted a large cohort study and asked the question of which glucose level should be targeted [ 66].
Self-administered FFQs were used in all of the prospective cohorts, none of which were specifically designed for assessing GI or GL intake.
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